2009 Dec 15;54(25):2353-7. doi: 10.1016/j.jacc.2009.08.035. Kose M, Emet S, Akpinar TS, Kocaaga M, Cakmak R, Akarsu M, et al. The aim of this audit was to examine the use, efficacy and tolerability of high intensity statin treatment (simvastatin 80 mg; atorvastatin 80 mg) in primary care. Conclusion: Pharmaceutical risk reduction with high-intensity statin therapy is advisable for high-risk patients. Atorvastatin: Side effects, dosage, uses, and more - Medical News Today Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, et al. depends on your cholesterol results too, mybe you could negotiate a slightly higher 'target' to be achieved As a last resort there are alternatives to be found useful which are described on many statin user groups!! The typical starting dose of atorvastatin is 10 mg to 20 mg by mouth once daily. Not sure if statins will be put back on 40mg now after the heart attack. Comparison of atorvastatin 80 mg/day versus simvastatin 20 to 40 mg/day on frequency of cardiovascular events late (five years) after acute myocardial infarction (from the Incremental Decrease in End Points through Aggressive Lipid Lowering [IDEAL] trial) Am J Cardiol. The groups were also comparable regarding baseline lipid profiles, oxidized-LDL, and hematological parameters. Some people who need a larger reduction in . The site is secure. It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body. life/lifestyle is taking the meds. My neighbour is a prime example of statin taking over 14 years. Admission Endocan Level may be a Useful Predictor for In-Hospital Mortality and Coronary Severity Index in Patients With ST-Segment Elevation Myocardial Infarction. Give a copy of this list to your healthcare provider. Ive been eating healthy and Excersising. After centrifugation, serum samples were transferred to Eppendorf tubes and stored at 80 C until the assay. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Also, for most people the benefits of the meds outweigh the disadvantages, you're very lucky if your able to stop them my husbands meds are what's keeping him alive. official website and that any information you provide is encrypted On the other hand, when the decrease in LDL-C levels was examined in terms of percentage change, there was no statistically significant difference between the two groups (39% vs. 47%, p=0.091). Atorvastatin oral tablet is used to improve cholesterol levels and decrease your risk for heart attack. Sun H, Li Y, Sun B, Hou N, Yang J, Zheng M, Xu J, Wang J, Zhang Y, Zeng X, Shan C, Chang B, Chen L, Chang B. Your provider may increase your dose as needed to treat your high cholesterol. Take atorvastatin exactly as directed. I really think this is what you are suffering from and it is unrelated to your other conditions. No: BI-20022), Chemerin (BioVendor, Cat. Rosuvastatin 40 mg/day provided a statistically significant reduction in the absolute change of LDL-C levels (48 mg/dL vs. 63 mg/dL, p=0.039). Secondary objectives were to compare the effects of atorvastatin 40 mg vs 80 mg on HDL-C and triglycerides and also comparing of side effects (myopathy, hepatotoxicity and new onset diabetes mellitus) of both doses. DISCLAIMER: The topics and articles published on this website including text, graphics, videos info graph and other material are for informational purposes only and should not be substituted for professional medical advice. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Developed with the special contribution of the European Assocciation for Cardiovascular Prevention &Rehabilitation (EACPR). Ho JE, Liu CY, Lyass A, Courchesne P, Pencina MJ, Vasan RS, et al. Previous studies have shown the association between the endocan levels and CAD, AMI, newly diagnosed hypertension, and coronary ectasia (9, 10, 31, 32). Of the 106 patients enrolled in this study, 63 (59%) subjects had a baseline plasma specimen available for the measurement of endocan, chemerin, and galectin-3. Statins include atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin, rosuvastatin (Crestor) and simvastatin (Zocor). Chemerin levels significantly decreased in both groups according to baseline [from 264.90 (196.00525.95) ng/mL to 135.00 (105.95225.65) ng/mL with atorvastatin 80 mg and from 309.95 (168.87701.27) ng/mL to 121.25 (86.60212.65) ng/mL with rosuvastatin 40 mg, p<0.001, respectively, for both groups, Table 2 and Fig. You may still have some of the first drugs still being cleared through your system, so Co- enzymes may help. Are statins created equal? Discussion: According to our findings, the effect of atorvastatin 80 mg/day on chemerin levels was limited, while rosuvastatin 40 mg/day significantly reduced the serum chemerin levels at the end of 4-week therapy (Table 2). Dangers of Statin Drugs: What You Haven't Been Told About Popular National Library of Medicine 2006 Feb;151(2):273-81. doi: 10.1016/j.ahj.2005.04.003. Xiaotao L, Xiaoxia Z, Yue X, Liye W. Serum chemerin levels are associated with the presence and extent of coronary artery disease. 8600 Rockville Pike Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Ganiats TG, Holmes DR, Jr, et al. According our findings, both statins significantly reduced the serum endocan levels at the end of 4-week therapy, and these results may be another important evidence for understanding the pathophysiological mechanisms of the pleiotropic effects of statins in patients with AMI. AdultsAt first, 10 or 20 milligrams (mg) once a day. my Pharmacist told me that he knew more about pills and potions than any Dr.so,if I was.anxious about side-effects?he would gladly take me into a private room and discuss my options..he knew I had stopped the statins.andhe did not say I must go back to taking anythat made life easier, though until this very moment? Statin side effects: Weigh the benefits and risks - Mayo Clinic Our study has some limitations. Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, et al. All is OK so I am advised to carry on. Total cardiovascular disease burden: comparing intensive with moderate statin therapy insights from the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) trial. The chi-squared test was used for comparing categorical variables. Interesting, do you consider taking 40mg atorvastatin since 2012 was a major benefit to you in that the heart attack could have had fatal consequences if you had not been taking statins. High-intensity statin therapy yields better outcomes in acute coronary syndrome patients: a meta-analysis involving 26,497 patients. You need to try out different medications to get the right ones for you, its a long process as there are so many, but its worth it . Rosuvastatin 40 mg significantly reduced LDL-C levels when compared with atorvastatin 80 mg. Rosuvastatin 40 mg seems to have more prominent effects on the levels of chemerin and galectin-3, whereas the two high-dose statin regimens have similar effects on the levels of endocan. In our study, rosuvastatin 40 mg resulted in further reductions in LDL-C levels when compared with atorvastatin 80 mg. Atorvastatin 80 mg led to a 39% and rosuvastatin 40 mg led to a 47% reduction of LDL-C levels from baseline, respectively, at the end of 4 weeks. Sometimes I think the consultant is the best one to talk to rather than the GP for obvious reasons, I know this can be difficult, but its your health, so don't be bothered about talking to them at length, these days you must push to get the time you deserve. Atorvastatin (Oral Route) Proper Use - Mayo Clinic government site. 2]. Careers, Unable to load your collection due to an error. ; Literature search A.T., B.., C.A. Bethesda, MD 20894, Web Policies Nicholls SJ, Brandrup-Wognsen G, Palmer M, Barter PJ. The ST elevation was defined as a new ST elevation at the J point in at least 2 contiguous leads 2 mm (0.2 mV) in men or 1.5 mm (0.15 mV) in women in leads V2V3 and/or 1 mm (0.1 mV) in other contiguous chest leads or the limb leads (24). I'd expect 10mg rosuvastatin next, then if that doesn't work 40mg simvastatin. Epub 2011 Oct 21. Kundi H, Balun A, Cicekcioglu H, Karayigit O, Topcuoglu C, Kilinckaya MF, et al. Careers. ; Design A.T., B.B.A., M.U.Y. FAQ Note: This document contains side effect information about atorvastatin. and transmitted securely. Change of galectin-3 levels with atorvastatin 80 mg and rosuvastatin 40 mg at end of 4-week therapy. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, et al. Swindle JP, Potash J, Kulakodlu M, Kuznik A, Buikema A. Ask your doctor to explain ANYTHING and EVERYTHING you don't understand. NSTEMI was defined according to the current guideline for the management of patients with non-ST-elevation ACS (25). Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) Investigators. We analyzed the same composite end point used in the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT) trial (death, MI, hospitalization for unstable angina, revascularization, and stroke). (40) described the stimulating effects of chemerin on vascular smooth muscle cell proliferation and carotid neointimal hyperplasia. And if you can get by with taking the 80mg then thats the best thing for you. Hi,I follow regularly BHF posts and find them all reassuring, I have a question on Atorvastatin, I had a stent implant Dec 2016 and take 80mg Atorvastin plus Ramipril 125mg and Aspirin 75mg, My GP suggested to reduce this to 40mg but requested first a blood test after the results she decided to keep me on 80mg Atorvastatin as my cholesterol was 4.3. come off 80mg atorvastatin feel a lot - Cholesterol Support Neunteufl T, Katzenschlager R, Hassan A, Klaar U, Schwarzacher S, Glogar D, et al. Wasn't mentioned in my discharge notes, or by my GP on the couple of times I've seen them in the past 9 months. Fasting blood samples were taken before the randomization within 24 hours and at the end of the 4-week period of the therapy by a cubital venipuncture avoiding venous stasis to an evacuated serum separator tube. Summary Common side effects of Lipitor include: hemorrhagic stroke, arthralgia, diarrhea, and nasopharyngitis. This site needs JavaScript to work properly. After revascularization therapy, patients were randomly assigned to receive atorvastatin (80 mg/day) or rosuvastatin (40 mg/day). Rosen ED, Spiegelman BM. Atorvastatin is used together with diet, weight loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits. Am Heart J. please ive had a triple by pass op whch failed within months had 2 stents and for over a year now ive had a problem when out walking my head is light headed/dizzy getting worse sitting down driving etc ive had all the tests at cardiac nothing found been to ent its not vertigo at neurology now they think it maybe post-ictal depression mild/moderate not sure tho ive not worked in 2 yrs can any one help me please just want some quality of life back thanks. This site needs JavaScript to work properly. You and your body have been through such a lot. thank you so much for your advice take care god bless. Epub 2019 Oct 12. They showed that simvastatin and simvastatin plus ezetimibe combination decreased the levels of adipokines. An official website of the United States government. Children 10 years of age and older with heterozygous familial hypercholesterolemia (HeFH)At first, 10 mg once a day. HHS Vulnerability Disclosure, Help Both statins have similar favorable effects on endocan, whereas rosuvastatin 40 mg/day seems to be more effective in terms of ability to decrease chemerin and galectin-3 levels. There were no significant differences between the two groups among the baseline levels of endocan, chemerin, and galectin-3 (Table 1). The effect of simvastatin-ezetimibe combination therapy on adipose tissue hormones and systemic inflammation in patients with isolated hypercholesterolemia. Hubby has been on 80mg for the last 12 years following HA and stent. Uses Warnings Before taking Side effects Interactions Dosage FAQ What is Lipitor? The .gov means its official. Weng TC, Yang YH, Lin SJ, Tai SH. 2022 Jun 28;2022:2751750. doi: 10.1155/2022/2751750. Lipitor: How does this statin affect cholesterol levels? 2005 Oct 18;46(8):1405-10. doi: 10.1016/j.jacc.2005.03.077. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. A medication error is defined as any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the healthcare professional, patient, or consumer, according to the National Coordinating Council for Medication Error Reporting and Prevention. Keep an updated list of all medications taken for health reasons, including OTC drugs, supplements, medicinal herbs, and other substances. Xiong C, Zhao ZW, Chen ZY, Wu LZ, Luo YK, Hu FD, et al. Had no problems with it. Lipitor Dosage: Form, Strengths, How to Take, and More - Healthline Endocan, a new endothelial marker in human sepsis. FOIA Can I ask what is the benefit you expect to gain from this approach which seems advocated by your GPs - what is the rationale they explain as to why this is necessary. Imran TF, Shin HJ, Mathenge N, Wang F, Kim B, Joseph J, et al. Bookshelf The absolute and percentage changes of lipid parameters after 4-week therapy in both groups are listed in Table 3. Meta-Analysis of the Usefulness of Plasma Galectin-3 to Predict the Risk of Mortality in Patients With Heart Failure and in the General Population. When I had my stent last year, the hospital put me on 80mg. The comparison between two doses revealed a non-significant difference (p = .118 & p = .149 respectively). "put me back on 20mg statin" - if he's put you back on atorvastatin after an adverse reaction, then ask to change statin. (adsbygoogle = window.adsbygoogle || []).push({}); Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). 2021 Dec 8;12:693397. doi: 10.3389/fneur.2021.693397. Im on 80mg and my last blood test showed cholesterol was 2.4, no mention of lowering dose and Im fine with that. To study the effect of high dose Atorvastatin 40 mg versus 80 mg in Atorvastatin: Cholesterol, Uses, Side Effects, Dosages - RxList This is a process of elimination if nobody can be sure whether her legs' inability to . Accessibility Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Keep trying - but give changes a chance to show their worth., hope you do find something safe and acceptable. In a recent study, Xiong et al. Comparison of atorvastatin 80 mg/day versus simvastatin 20 to - PubMed If you are having no problems and LFT (liver function tests) are OK I would carry on as you are. doi: 10.1097/MD.0000000000004906. I do NOT want statin side-effect hell ever again and believe specialist-led treatment gives me the best chance of avoiding that. Acute myocardial infarction. HHS Vulnerability Disclosure, Help In a small study, 15 statin-naive patients with atherosclerosis were given atorvastatin 40 mg/day for 12 weeks, and at the end of study, galectin-3 levels decreased non-significantly (47). Our results indicate that, although not significant, rosuvastatin 40 mg/day seems to be more effective on galectin-3 levels when compared with atorvastatin 80 mg/day. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. *Department of Cardiology, Faculty of Medicine, Seluk University; Konya-Turkey, **Department of Biochemistry, Faculty of Medicine, Seluk University; Konya-Turkey. Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial. Thanks, interesting to get others views. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. A total of 106 patients hospitalized in the coronary intensive care unit of Seluk University Faculty of Medicine Department of Cardiology between January 2015 and December 2016 with STEMI and Non-ST-elevation myocardial infarction (NSTEMI) and eligible for our study were enrolled (23). Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis. For this reason, we do not know any information whether there are any long-term effects of statins on these biomarkers, and whether these effects are associated with hard endpoints, such as death and myocardial infarction. Bethesda, MD 20894, Web Policies Janma123 4 years ago. MeSH not on statins. can any one please advice me please ive tried 3 different statin drugs ive stopped them now feel so much better but my cholesterol has gone. ; Funding A.T., C.A., N.A., K.D., F.A. We designed and conducted a study to investigate and compare the effects of atorvastatin 80 mg and rosuvastatin 40 mg on the lipid profiles and the levels of endocan, chemerin, and galectin-3 in patients with AMI who underwent revascularization as a substudy of a previous article investigating the effects of atorvastatin 80 mg and rosuvastatin 40 mg on the plasma PCSK-9 levels in patients with AMI who underwent revascularization (23). 2011 Mar-Apr;18(2):110-6. doi: 10.1097/MJT.0b013e3181cf12d2. 80 is certainly high and more than a regular kind of dose that eg one's partner may be taking. ive not herd about that thank you for your help im seeing my gp today take care. My Cardiologist recommended staying on that dose, as long as my body could tolerate it, he said. Abstract of this article presented as poster abstract at the 23rd International Congress of Clinical Chemistry and Laboratory Medicine Congress, helded at the Durban International Convention Center in Durban, South Africa on October 22-25, 2017. 8600 Rockville Pike LFT should be carried out 4 - 6 weeks after commencement of statins or increase in dose, and regularly thereafter even if things appear stable. Levels of LDL-C were calculated by using the Friedewald formula. Comparison of baseline clinical characteristics and laboratory parameters of the patients, Data given as meanstandard deviation or number (%), ALT - alanine aminotransferase; AST - aspartate aminotransferase; BUN - blood urea nitrogen; CK - creatine kinase; DBP - diastolic blood pressure; HDL-C - high-density lipoprotein cholesterol; Hb - hemoglobin; LDL-C - low-density lipoprotein cholesterol; LVEF - left ventricular ejection fraction; TC - total cholesterol; Oxidized-LDL - oxidized low-density lipoprotein cholesterol; SBP - systolic blood pressure; STEMI - ST segment elevation myocardial infarction; WBC - white blood cells. Comparison of atorvastatin and rosuvastatin by means of absolute and percentage change of laboratory parameters. The TNT-Trial showed that atorvastatin 80 mg provided a significant clinical benefit beyond that provided by atorvastatin 10 mg (27). Adipose tissue is an active endocrine organ and regulates energy homeostasis and metabolism by communicating with liver, skeletal muscle, and brain via secreted soluble protein hormones (also called as adipokines) (11, 12). If your liver enzymes are already elevated, you should not be taking any statin drugs. The aim of this study is to investigate and compare the effects of high doses of atorvastatin and rosuvastatin on serum endocan, chemerin, and galectin-3 levels in patients with acute myocardial infarction (AMI). Distribution of continuous variables was tested using the KolmogorovSmirnov test. The percentage change of endocan was 7.96 (43.7527.64) % with atorvastatin 80 mg and 26.61 (46.5615.65) % with rosuvastatin 40 mg, and there was no statistically significant difference between groups (p=0.349, Table 3). Pitt B, Loscalzo J, Monyak J, Miller E, Raichlen J. official website and that any information you provide is encrypted Boekholdt SM, Hack CE, Sandhu MS, Luben R, Bingham SA, Wareham NJ, et al. Front Neurol. Atorvastatin Side Effects: Common, Severe, Long Term To view profiles and participate in discussions please. This retrospective observational study suggests that despite national guidelines, atorvastatin 80 mg is used in clinical practice and is more effective and at least as well tolerated as simvastatin 80 mg. We reported that both statins similarly decreased the endocan levels, whereas rosuvastatin seems to have more prominent effects on the reduction of the chemerin and galectin-3 levels in patients with AMI. In another study, admission endocan levels were found to be associated with in-hospital mortality and the CAD severity index in patients with ST segment elevation myocardial infarction (STEMI) (10). Baseline characteristics, as well as post-treatment changes, were compared within groups by using a paired-sample t-test or Wilcoxon signed-ranks test. Print Save Atorvastatin Dosage Medically reviewed by Drugs.com. Evidence from randomized trials of pravastatin, simvastatin, and atorvastatin for cardiovascular disease prevention. Treating to New Targets (TNT) Investigators. FOIA Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. Endocan levels were not decreased statistically significantly with atorvastatin 80 mg, but rosuvastatin 40 mg markedly decreased the levels of endocan according to baseline [from 110.27 (86.03143.69) pg/mL to 99.22 (78.30122.87) pg/mL with atorvastatin 80 mg and from 110.73 (77.28165.22) pg/mL to 93.40 (70.48115.13) pg/mL with rosuvastatin 40 mg, p=0.242 for atorvastatin 80 mg and p=0.014 for rosuvastatin 40 mg]. The https:// ensures that you are connecting to the Galectin-3 serum concentrations were measured with a chemiluminescent microparticle immunoassay on an ARCHITECT i1000SR auto analyzer (Abbott Diagnostics). ; Data collection and/or processing A.T., B.., M.S.A., H.T., C.A., E.C.K., F.A. Children 10 years of age and older with heterozygous familial hypercholesterolemia (HeFH)At first, 10 mg once a day. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. Krysiak et al. My GP told me this is fairly standard after a heart attack, but she was happy to reduce it to 40mg as I was rather stressed about the whole heart attack business and the statins were distressing me as much as anything else. But then I think if I was on the 80mg from the start would it of prevented the heart attack? Is 40 mg of atorvastatin too much? Applies to the following strengths: 10 mg; 20 mg; 40 mg; 80 mg; 20 mg/5 mL Usual Adult Dose for: Prevention of Cardiovascular Disease Homozygous Familial Hypercholesterolemia Hyperlipidemia Hyperlipoproteinemia Type IIa (Elevated LDL) First, relatively small differences between the two different drug groups may not have reached statistical significance due to the limited number of patients, and our study is a substudy of another investigation and carries the common disadvantages of substudies. However, its worth asking them as they should be doing it, Since heart attack and stents only blood tests I have had were whilst in hosp for 3 days in March, I did ask my DR if I required test and he said no. Lipitor Side Effects: Common, Severe, Long Term - Drugs.com come off 80mg atorvastatin feel a lot better now gp has put me back on 20mg statin and 10mg ezetimibe symptons returned in days any advice. Change of endocan levels with atorvastatin 80 mg and rosuvastatin 40 mg at end of 4-week therapy. Statistical analyses were performed using the SPSS for Mac version 20.0 (SPSS Inc., Chicago, Illinois, USA). I know that sounds a bit trite and I have not been in your position, I'm sure there are others on here who have and can help you. Disclaimer. The site is secure. Consult with your doctor about this issue. Enhanced-Dose Statins for ST-Segment Elevation Myocardial Infarction Patients after Emergency Percutaneous Coronary Intervention. Immunohistochemical analysis revealed that endocan is highly expressed in these plaques, and the authors hypothesized that endocan may contribute the neointimal formation process during atherosclerosis (6). However, depending on the dose, signs of an overdose on this drug can include: trouble breathing due to allergic reaction, passing out, jaundice, indicating liver damage, dark urine/muscle pain, indicating rhabdomyolysis and kidney damage and seizures. My personal experiences is that I prefer to reduce or eliminate all medications if at all possible as all drugs have unwanted side effects. Have a cardiology follow-up this afternoon so that's another one to add to the question list. I am no longer taking either.I put up with the pain,and take life very much easier,so,as to give my heart a chance. Effects of statins beyond lipid lowering:potential for clinical benefits. We know from previous studies that atorvastatin 80 mg and rosuvastatin 40 mg are the most potent statins (26). . Atorvastatin ( Lipitor) is a medication prescribed by a doctor to lower cholesterol in people who have been diagnosed with high cholesterol (high levels of cholesterol in the blood). 37 According to the abstract: "For patients with acute coronary syndrome, lipid-lowering therapy with atorvastatin, 80 mg/day, reduced recurrent ischemic events in the first 16 weeks . It is associated with obesity, metabolic syndrome, and inflammation. In addition to statin therapy, acetyl salicylic acid, clopidogrel, or ticagrelor/prasugrel were prescribed in all patients. I seem fine on that dosage, so will continue. Results: A total of 116 patients had taken simvastatin 80 mg or atorvastatin 80 mg. This finding is consistent with previous studies. Serum Endocan Level and the Severity of Coronary Artery Disease:A Pilot Study. 2010 Aug 1 . More patients on simvastatin withdrew from treatment as a result of inefficacy (49.3% vs. 23.2%, p=0.025) compared with the atorvastatin group. Hubby has been on 80mg for the last 12 years following HA and stent. One of the landmark articles about the effectiveness of high-dose statins is the TNT-Trial (27).
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